C to U RNA Editing Web Site
Purpose:
- This site is intended to act as a source of
information on the C to U type of RNA editing that occurs in plant mitochondria
and chloroplasts and in apoB in mammals, and to increase the interactions
between researchers in this field. A list of all researchers and their email
addresses and any available postdoctoral positions, literature references,
sequence databases specific for this field, and upcoming scientific meetings
will be presented. In addition, there will be a section with data taken from
published and unpublished research to illustrate research problems and research
directions.
I. Plant mitochondria and chloroplast
editing
-
A nice
introduction
to plant RNA editing by Phillip McClean.
-
List of selected literature references:
- Covello, P. S., Gray, M. W. RNA editing in plant mitochondria. Nature
341: 662-667 (1989) (MED)
- Freyer, R., Kiefer-Meyer, M. C., Kossel, H. Occurrence of plastid RNA
editing in all major lineages of land plants. Proc. Natl. Acad. Sci. 94:
6285-6290 (1997) (MED)
- Chaudhuri, S., Carrer, H., Maliga, P. Site-specific factor involved
in the editing of the psbL MRNA in tobacco plasdtids. EMBO J. 14: 2950-2957
(1995)
(MED)
- Chaudhuri, S., Maliga, P. Sequences directing C to U editing of the
plastid psbL mRNA are located within a 22 nucleotide segment spanning the
editing site. EMBO J. 15: 5958-5964 (1996) (MED)
- Kubo, N., Kadowaki, K. Involvement of 5’ flanking sequence for
specifying RNA editing sites in plant mitochondria. FEBS Letters 413: 40-44
(1997) (MED)
- Bock, R., Koop, H. Extraplastidic site-specific factors mediate RNA
editing in chloroplasts. EMBO J. 16: 3282-3288 (1997) (MED)
- Bock, R., Hermann, M., Fuchs, M. Identification of critical
nucleotide positions for plastid RNA editing site recognition. RNA 3: 1194-1200
(1997) (MED)
- Miyamoto T, Obokata J, Sugiura M. Recognition of RNA editing sites
is directed by unique proteins in chloroplasts: biochemical identification of
cis-acting elements and trans-acting factors involved in RNA editing in tobacco
and pea chloroplasts. Mol Cell Biol. 2002 Oct;22(19):6726-34.
(MED)
II. Apo B mRNA Editing
-
List of selected literature references:
- Backus, J. W., Smith, H. C. Three distinct RNA sequence elements are
required for efficient apolipoprotein B (apoB) RNA editing in vitro.
Nucl. Acids Res. 20: 6007-6014 (1992)
(MED)
- Hersberger, M., Innerarity, T. L.. Two Efficiency Elements Flanking
the Editing Site of Cytidine 6666 in the Apolipoprotein B mRNA Support
Mooring-dependent Editing. J. of Biol. Chem. 273: 9435-9442 (1998) (MED)
- Sowden, M. P., Eagleton, M. J., Smith, H. C. Apolipoprotein B RNA
sequence 3’ of the mooring sequence and cellular sources of auxiliary
factors determine the location and extent of promiscuous editing. Nucl. Acids
Res. 26: 1644-4652 (1998) (MED)
- Teng, B., Burant, C. F., Davidson, N. O. Molecular Cloning of an
Apolipoprotein B Messenger RNA Editing Protein. Science 260: 1816-1819 (1993)
(MED)
- Fujino, T., Navaratnam, N., Scott J. Human Apolipoprotein B RNA
Editing Deaminase Gene (APOBEC1). Genomics 47: 266-275 (1998) (MED)
- Anant, S., MacGinnitie, A. J. Davidson, N. O. Apobec-1, the Catalytic
Subunit of the Mammalian Apolipoprotein B mRNA Editing Enzyme, Is a Novel
RNA-binding Protein. J. Biol. Chem. 270: 14762-14767 (1995) (MED)
- Navaratnam, N., Fujino, T., Bayliss, J., Jarmuz, A., How, A.,
Richardson, N., Somasekaram, A., Bhattacharya, S., Carter, C., Scott, J.
Escherichia coli Cytidine Deaminase Provides a Molecular Model for ApoB
RNA Editing and a Mechanism for RNA Substrate Recognition. J. Mol. Biol. 275:
695-714 (1998) (MED)
- Mehta, A., Banerjee, S., Driscoll, D. M. Apobec-1 Interacts with a
65-kDa Complementing Protein to Edit Apolipoprotein-B mRNA in Vitro. J.
Biol. Chem. 271: 28294-28299 (1996) (MED)
- Mehta, A., Driscoll, D. M. A Sequence-Specific RNA-Binding Protein
Complements Apobec-1 To Edit Apolipoprotein B mRNA. Mol. & Cell. Biol. 18:
4426-4432 (1998) (MED)
- Nakamuta, M., Tsai, A., Chan, L., Davidson, N. O., Teng, B. Sequence
Elements Required for Apolipoprotein B mRNA Editing Enhancement Activity from
Chicken Enterocytes. Biochem. & Biophy. Res. Comm. 254: 744-750 (1999) (MED)
- Mehta A, Kinter MT, Sherman NE, Driscoll DM. Molecular cloning of
apobec-1 complementation factor, a novel RNA-binding protein involved in the
editing of apolipoprotein B mRNA. Mol Cell Biol. 2000 Mar;20(5):1846-54.
(MED)
- YANG, Y., BALLATORI, N. & SMITH, H.C. Synthesis and secretion of
the atherogenic risk factor apoB100 is reduced through TAT-mediated protein
transduction of an mRNA editase into hepatocytes. Molec. Pharm 61:269-276
(2002).
- SOWDEN, M.P., BALLATORI, N., DE MESY JENSEN, K., HAMILTON REED, L.
& SMITH, H.C. The editosomes for cytidine to uridine mRNA editing has a
native complexity of 27S: identification of intracellular domains containing
active and inactive editng factors. J. Cell Sci. 115:1027-1039 (2002).
- DANCE, G.F.C., SOWDEN, M.P., L. CARTEGNI, COOPER, E., KRAINER, A.
& SMITH, H.C. Two proteins essential for apolipoprotein B mRNA Editing are
expressed from a single gene through alternative splicing. J. Biol. Chem.
277:12703-12709 (2002).
- Anant S, Davidson NO. Identification and regulation of protein
components of the apolipoprotein B mRNA editing enzyme. A complex event. Trends
Cardiovasc Med. 2002 Oct;12(7):311-7. Review. (MED)
- Blanc V, Davidson NO. C-to-U RNA editing: mechanisms leading to
genetic diversity. J Biol Chem. 2003 Jan 17;278(3):1395-8. Review. (MED)
- Mukhopadhyay D, Anant S, Lee RM, Kennedy S, Viskochil D, Davidson
NO. C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express
both the type II transcript and apobec-1, the catalytic subunit of the
apolipoprotein B mRNA-editing enzyme. Am J Hum Genet. 2002 Jan;70(1):38-50. (MED)
- Henderson JO, Blanc V, Davidson NO. Characterization and
developmental regulation of the human apobec-1 complementation factor (ACF)
gene. Biochim Biophys Acta. 2001 Nov 11;1522(1):22-30. (MED)
- Anant S, Davidson NO. An AU-rich sequence element (UUUN[A/U]U)
downstream of the edited C in apolipoprotein B mRNA is a high-affinity binding
site for Apobec-1: binding of Apobec-1 to this motif in the 3' untranslated
region of c-myc increases mRNA stability. Mol Cell Biol. 2000
Mar;20(6):1982-92.
(MED)
- Blanc V, Henderson JO, Kennedy S, Davidson NO. Mutagenesis of
apobec-1 complementation factor reveals distinct domains that modulate RNA
binding, protein-protein interaction with apobec-1, and complementation of C to
U RNA-editing activity. J Biol Chem. 2001 Dec 7;276(49):46386-93.
(MED)
- Sowden M, Hamm JK, Smith HC. Overexpression of APOBEC-1 results in
mooring sequence-dependent promiscuous RNA editing. J Biol Chem. 1996 Feb
9;271(6):3011-7.
(MED)
Activation-Induced Cytidine Deaminase (AID)
- Greeve J, Philipsen A, Krause K, Klapper W, Heidorn K, Castle BE,
Janda J, Marcu KB, Parwaresch R. Related Articles, Links Expression of
activation-induced cytidine deaminase in human B-cell non-Hodgkin's lymphomas.
Blood. 2003 Jan 2
(MED)
- Nagaoka H, Muramatsu M, Yamamura N, Kinoshita K, Honjo T.
Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin
Smu region: implication of AID involvement in a common step of class switch
recombination and somatic hypermutation. J Exp Med. 2002 Feb 18;195(4):529-34
(MED)
- Okazaki IM, Kinoshita K, Muramatsu M, Yoshikawa K, Honjo T. The AID
enzyme induces class switch recombination in fibroblasts. Nature. 2002 Mar
21;416(6878):340-5.
(MED)
List of Researchers in this field:
A photo of the
people at the 1999 RNA Editing Gordon Conference in Ventura, CA
Please email me the URL of your home page and I will add it to your
entry (simpson@kdna.ucla.edu).
Links to other related web sites:
You Are Visitor Number
to this Page since
2-25-2004
To return to the main RNA Editing site, click
here.
Created and maintained by L.
Simpson. Last revised on 6-30-2004
