Bibliography of Larry Simpson

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This Week in PNAS - a Featured Article

Unusual mitochondrial ribosome from a parasite

Complexes of proteins and RNA known as ribosomes play the crucial task of translating genetic messages, in the form of mRNAs, into proteins. Ubiquitous in eubacterial, eukaryotic cells, in the archaea, and in organelles, these workhorses of the genetic information system differ markedly in composition among the phylogenetic domains. Manjuli Sharma et al. found that the mitochondrial ribosome of the Leishmania tarentolae (Lmr) parasite contains several features previously unseen in cytoplasmic or organellar ribosomes. The Leishmania parasites, which are transmitted by the bite of sand flies, cause skin sores or potentially fatal visceral disease. The authors obtained a 3D, cryo-electron microscopic map of the Lmr parasite and discovered that, in addition to having lower RNA content, this mitochondrial ribosome was more porous than other known ribosome structures. Major portions of key functionally conserved sites, such as the channel where mRNA enters, the transfer RNA passage, and the region where nascent polypeptides exit, contain Lmr-specific proteins, rather than familiar ones. Despite the specificity in these regions, the overall architecture of the Lmr has been conserved, the authors say, suggesting the imposition of tight constraints on this evolutionarily divergent ribosomal form. — F.A.

Structure of a mitochondrial ribosome with minimal RNA by Manjuli R. Sharma, Timothy M. Booth, Larry Simpson, Dmitri A. Maslov, and Rajendra K. Agrawal (see pages 9637-9642)


                                                                                  Papers

1963

1. Simpson, L., Kirby-Smith, J. and Randolph, M., "Electron spin resonance in photodynamic dyes.", Nature 199, 243-245 (1963) (PDF)

1966

2. Simpson, L., "Toxic impurities in Nalgene filter units.", Science 153, 548 (1966) (PDF)

1967

3. Simpson, L., "Morphogenesis and the function of the kinetoplast in Leishmania.", Atlas de Symposia sobre a Biota Amazonica (Pathologia) 6, 231-234 (1967) (PDF)

1968

4. Simpson, L., "Behavior of the kinetoplast of Leishmania tarentolae.", J. Protozool. 15, 132-136 (1968) (PDF)

5. Simpson, L., "The leishmania-leptomonad transformation of Leishmania donovani: nutritional requirements, respiration changes and antigenic changes.", J. Protozool. 15, 201-207 (1968) (PDF)

6. Simpson, L., "The effects of acriflavin on the kinetoplast DNA of Leishmania tarentolae: mechanism of action and physiological correlates of the loss of kinetoplast DNA.", J. Cell Biol. 37, 660-682 (1968) (PDF)

1970

7. Simpson, L. and Braly, P., "Synchronization of Leishmania tarentolae by hydroxyurea.", J. Protozool. 17, 511-517 (1970) (PDF)

1971

8. Simpson, L. and da Silva, A., "Isolation and characterization of kinetoplast DNA from Leishmania tarentolae. ", J. Mol. Biol. 56, 443-473 (1971)  (PDF)

1972

9. Simpson, L., "The kinetoplast of the hemoflagellates.", Intern. Rev. Cytol. 32, 139-207 (1972) (PDF)

1973

10. Simpson, L., "Structure and function of the kinetoplast DNA.", J. Protozool. 20, 2-8 (1973) (PDF)

11. Wesley, R.D. and Simpson, L., "Studies on kinetoplast DNA. I. Isolation of kinetoplast DNA minicircles from Leishmania tarentolae.", Biochim. Biophys. Acta 319, 237-253 (1973) (PDF)

12. Wesley, R.D. and Simpson, L., "Studies on kinetoplast DNA. II. Biophysical properties of minicircular DNA from Leishmania tarentolae.", Biochim. Biophys. Acta 319, 254-266 (1973)  (PDF)

13. Wesley, R.D. and Simpson, L., "Studies on kinetoplast DNA. III. Kinetic complexity of kinetoplast and nuclear DNA from Leishmania tarentolae.", Biochim. Biophys. Acta 319, 267-276 (1973)  (PDF)

14. Salser, W., Fry, K., Wesley, R.D. and Simpson, L., "Use of nucleic acid fingerprints to estimate the complexity of minicircle DNA.", Biochim. Biophys. Acta 319, 277-280 (1973)  (PDF)

1974

15. Simpson, A. and Simpson, L., "Labeling of Crithidia fasciculata DNA with 3H-thymidine.", J. Protozool. 21, 379-382 (1974) (PDF)

16. Simpson, L. and Berliner, J., "Isolation of the kinetoplast DNA of Leishmania tarentolae in the form of a network.", J. Protozool. 21, 382-393 (1974) (PDF)

17. Simpson, L., Simpson, A. and Wesley, R., "Replication of the kinetoplast DNA of Leishmania tarentolae and Crithidia fasciculata.", Biochim. Biophys. Acta 349, 161-172 (1974) (PDF)

18. Braly, P., Simpson, L. and Kretzer, F., "Isolation of kinetoplast-mitochondrial complexes from Leishmania tarentolae.", J. Protozool. 21, 782-790 (1974)  (PDF)

19. Simpson, L. and Simpson, A., "Isolation and characterization of kinetoplast DNA networks from Crithidia fasciculata.", J. Protozool. 21, 774-781 (1974)  (PDF)

20. Greenfield, L., Simpson, L. and Kaplan, D., "Conversion of closed circular DNA molecules to single-nicked molecules by digestion with DNAse I in the presence of ethidium bromide.", Biochim. Biophys. Acta. 407, 365-375 (1975)  (PDF)

1976

21. Simpson, A. and Simpson, L., "Pulse-labeling of kinetoplast DNA: Localization of two sites of synthesis within the networks and kinetics of labeling of closed minicircles.", J. Protozool. 23, 583-587 (1976) (PDF)

22. Simpson, L. and Hyman, B., "Restriction enzyme analysis of Leishmania tarentolae kinetoplast DNA.", in Biochemistry of Parasites and Host-Parasite Relationships (H. Van den Bosche, ed.) North-Holland Pub. Co., Amsterdam, (1976) (PDF)

23. Simpson, L., Simpson, A. and Lasky, L., "Kinetoplast RNA from Leishmania tarentolae culture forms.", in Biochemistry of Parasites and Host-Parasite Relationships (H. Van den Bosche, ed.) North Holland Pub. Co. Amsterdam, (1976) (PDF)

1977

24. Brunk, C. and Simpson, L., "Comparison of various ultraviolet sources for fluorescent detection of ethidium bromide-DNA complexes in polyacrylamide gels.", Anal. Biochem. 82, 455-462 (1977) (PDF)

1978

25. Simpson, L., "Glucose-sensitive strain of Trypanosoma brucei.", J. Parasitol. 64, 360 (1978) (PDF) 

26. Simpson, L. and Simpson, A., "Kinetoplast RNA of Leishmania tarentolae.", Cell 14, 169-178 (1978) (PDF)

27. Cheng, D. and Simpson, L., "Isolation and characterization of kinetoplast DNA and RNA of Phytomonas davidi.", Plasmid 1, 279-315 (1978) (PDF)

1979

28. Masuda, H., Simpson, L., Rosenblatt, H. and Simpson, A., "Restriction map, partial cloning and localization of 9S and 12S RNA genes on the maxicircle component of the kinetoplast DNA of Leishmania tarentolae. ", Gene 6, 51-73 (1979) (PDF)

29. Simpson, L., "Isolation of maxicircle component of kinetoplast DNA from hemoflagellate protozoa.", Proc. Natl. Acad. Sci. USA 76, 1585-1588 (1979)  (PDF)

30. Simpson, L., Simpson, A., Masuda, H., Rosenblatt, H., Michael, N. and Kidane, G., "Replication and transcription of kinetoplast DNA", In Extrachromosomal DNA (Cummings, D., Borst, P., David, I., Weissman, J. and Fox, C. eds.) ICN-UCLA Symposium. XV, 533-548 (1979) (PDF)

1980

31. Morel, C., Chiari, E., Camargo, E., Mattei, D., Romanha, A. and Simpson, L., "Strains and clones of Trypanosoma cruzi can be characterized by restriction endonuclease fingerprinting of kinetoplast DNA minicircles.", Proc. Natl. Acad. Sci. USA 77, 6810-681 (1980)  (PDF)

32. Simpson, L., Simpson, A., Kidane, G., Livingston, L. and Spithill, T., "The kinetoplast DNA of the hemoflagellate protozoa.", Am. J. Trop. Med. Hyg., Suppl. 29, 1053-1063 (1980) (PDF)

33. Morel, C. and Simpson, L., "Characterization of pathogenic trypanosomatidae by restriction endonuclease fingerprinting of kinetoplast DNA minicircles.", Am. J. Trop. Med. Hyg. 29 Suppl., 1070-1074 (1980) (PDF) 

34. Simpson,A. and Simpson, L., "Kinetoplast DNA and RNA of Trypanosoma brucei. ", Mol. Biochem. Parasitol. 2, 93-108 (1980)  (PDF)

1981

35. Simpson, L. Morel, C. and Simpson, A., "Biological role of extrachromosomal DNA.", In Modern Genetic Concepts and Techniques in the Study of Parasites (F. Michal, ed.) Schwabe and Co. AG Basel, 65-81 (1981)

1982

36. Simpson, L., Simpson, A., Spithill, T. and Livingston, L., "Sequence organization of maxicircle kinetoplast DNA from Leishmania tarentolae.", In Mitochondrial Genes (Borst, P., Attardi, G. and Slonimski, P., eds.) Cold Spring Harbor Symposium, 435-439 (1982) (PDF)

(PDF)37. Hughes, D., Schneider, C. and Simpson, L., "Isolation and characterization of drug resistant mutants of Crithidia fasciculata.", J. Parasitol. 68, 642-649 (1982) (PDF) 

38. Simpson, L., Simpson, A. and Livingston, L., "Transcription of the maxicircle kinetoplast DNA of Leishmania tarentolae.", Mol. Biochem. Parasitol. 6, 237-257 (1982) (PDF)

39. Simpson, L., Spithill,T. and Simpson, A., "Identification of maxicircle DNA sequences in Leishmania tarentolae homologous to sequences of specific yeast mitochondrial structural genes.", Mol. Biochem. Parasitol. 6, 253-263 (1982) (PDF) 

1983

40. Hughes, D., Simpson, L. and Schneider, C., "Flagellar adherence of Crithidia fasciculata cells in culture.", J. Protozool. 30, 635-641 (1983) (PDF) 

41. Muhich, M., Simpson, L. and Simpson, A., "Comparison of the maxicircle DNAs of Leishmania tarentolae and Trypanosoma brucei.", Proc. Natl. Acad. Sci. USA 80, 4060-4064 (1983)  (PDF)

42. Spithill, T., Simpson, A.M. and Simpson, L., "Identification of sequence homologies between maxicircle DNA of Leishmania tarentolae and specific yeast mitochondrial structural genes.",In Manipulation and Expression of Genes in Eukaryotes (Nagley, Linnane, Peacock and Pateman, eds.) Academic Press, Australia, 307-311 (1983)  (PDF)

1984

43. Simpson, L., "The application of recombinant DNA technology to problems of parasite and vector identification.", In New Approaches to the Identification of Parasites and Vectors (B. Newton and F. Michal, eds.) Schwabe AG, Basel, 71-95 (1984) (PDF)

44. Kidane, G., Hughes, D. and Simpson, L., "Sequence heterogeneity and anomalous electrophoretic mobility of kinetoplast minicircle DNA in Leishmania tarentolae.", Gene 27, 265-277 (1984) (PDF)

45. Hughes, D., Simpson, L., Kayne, P. and Neckelmann, N., "Autonomous replication sequences in the maxicircle kinetoplast DNA of Leishmania tarentolae.", Mol. Biochem. Parasitol. 13, 263-275 (1984) (PDF) 

46. de la Cruz, V., Neckelmann, N. and Simpson, L., "Sequences of six structural genes and several open reading frames in the kinetoplast maxicircle DNA of Leishmania tarentolae.", J. Biol. Chem. 259, 15136-15147 (1984)  (PDF)

47. Morel, C., Goncalves, A., Simpson, L. and Simpson, A.M., "Recent advances in the development of DNA hybridization probes for the detection and characterization of Trypanosoma cruzi.", Mem. Inst. Oswaldo Cruz Suppl. Vol. 79, 51-53 (1984) (PDF)

1985

48. de la Cruz, V.F., Lake, J.A., Simpson, A.M. and Simpson, L., "A minimal ribosomal RNA: Sequence and secondary structure of the 9S kinetoplast ribosomal RNA from Leishmania tarentolae.", Proc. Natl. Acad. Sci. USA 82, 1401-1405 (1985) (PDF) 

49. de la Cruz, V., Simpson, A., Lake, J. and Simpson, L., "Primary sequence and partial secondary structure of the 12s kinetoplast (mitochondrial) ribosomal RNA from Leishmania tarentolae: Conservation of peptidyl- transferase structural elements.", Nucl. Acids Res. 13, 2337-2356 (1985)  (PDF)

50. Muhich, M., Neckelmann, N. and Simpson, L., "The divergent region of the Leishmania tarentolae kinetoplast maxicircle DNA contains a diverse set of repetitive sequences.", Nucl. Acids Res. 13, 3241-3260 (1985) (PDF)

51. Simpson, A., Neckelmann, N., de la Cruz, V., Muhich, M. and Simpson, L., "Mapping and 5' end determination of kinetoplast maxicircle gene transcripts from Leishmania tarentolae.", Nucl.Acids Res. 13, 5977-5993 (1985) (PDF) 

52. Simpson, A., Hughes, D. and Simpson, L. , "Trypanosoma brucei: differentiation of in vitro-grown bloodstream trypomastigotes into procyclic forms.", J. Protozool. 32 , 672-677 (1985)  (PDF)

53. Simpson, L., Simpson, A., de la Cruz, V., Neckelmann, N. and Muhich, M., "Genomic organization and transcription of mitochondrial maxicircle DNA in trypanosomid protozoa.", In Achievements and Perspectives of Mitochodrial Research (Quagliarello, Slater, Palmieri, Saccone and Kroon, Eds.) Vol. II, Elsevier Press, p. 99-110 (1985) (PDF) 

1986

54. Hughes, D.E. and Simpson, L., "Introduction of plasmid DNA into the trypanosomatid protozoan Crithidia fasciculata", Proc. Natl. Acad. Sci. USA 83, 6058-6062 (1986)  (PDF)

55. Muhich, M. and Simpson, L., "Specific cleavage of kinetoplast minicircle DNA from Leishmania tarentolae and identification of several additional minicircle sequence classes", Nucl. Acids Res. 14, 5531-5556 (1986) (PDF) 

56. Simpson, L., "Kinetoplast DNA in trypanosomid flagellates.", Intern. Rev. Cytol. 99, 119-179 (1986)  (PDF)

57. Dewes, H., Ostergaard, H. and Simpson, L., "Impaired drug uptake in methotrexate resistant Crithidia fasciculata without changes in dihydrofolate reductase activity or gene amplification." Mol. Biochem. Parasitol. 19, 149-161 (1986) (PDF)

1987

58. Simpson, L., Neckelmann, N., de la Cruz, V., Simpson, A., Feagin, J., Jasmer, D. and Stuart, K., "Comparison of the maxicircle (mitochondrial) genomes of Leishmania tarentolae and Trypanosoma brucei at the level of nucleotide sequence.", J. Biol. Chem. 262, 6182-6196 (1987) (PDF)

59. Simpson, L., "The mitochondrial genome of kinetoplastid protozoa: genomic organization, transcription, replication and evolution.", Ann. Rev. Microbiol. 41, 363-382 (1987) (PDF)  

60. Muhich, M., Hughes, D., Simpson, A. and Simpson, L., "The monogenetic kinetoplastid protozoan, Crithidia fasciculata, contains a transcriptionally active, multicopy mini-exon sequence", Nucl. Acids Res. 15, 3141-3153 (1987) (PDF)

1988

61. Degrave, W., Fragoso, S., Britto, C., Van Heuverswyn, H., Kidane, K., Cardoso, M., Mueller, R., Simpson, L. and Morel, C., "Peculiar sequence organization of kinetoplast DNA minicircles from Trypanosoma cruzi", Mol. Biochem. Parasitol. 27, 63-70 (1988) (PDF)

62. Gomez-Eichelmann, C., Holz, G., Beach, D., Simpson, A. and Simpson, L., "Comparison of several lizard Leishmania species and strains in terms of kinetoplast minicircle and maxicircle DNA sequences, nuclear chromosomes and membrane lipids", Mol. Biochem. Parasitol. 27, 143-158 (1988) (PDF)

63. Feagin, J., Shaw, J., Simpson, L. and Stuart, K., "Creation of AUG initiation codons by addition of uridine within cytochrome b transcripts of three kinetoplastid species." Proc. Natl. Acad. Sci. USA. 85, 539-543 (1988) (PDF)

64. Lake, J., , de la Cruz, V., Ferreira, P., Morel, C. and Simpson, L., "Evolution of parasitism: Kinetoplastid protozoan history reconstructed from mitochondrial rRNA sequences." Proc. Natl. Acad. Sci. U.S.A. 85, 4779-4783 (1988) (PDF)

65. Shaw, J., Feagin, J., Stuart, K. and Simpson, L., "Editing of kinetoplastid mitochondrial mRNAs by uridine addition and deletion generates conserved amino acid sequences and AUG initiation codons." Cell. 53, 401-411 (1988) (PDF)

66. Simpson, L. and Holz, G., "The status of Leishmania tarentolae/Trypanosoma platydactyli." Parasitol. Today 4, 115-118 (1988) (PDF)

1989

67. Simpson, L., "Gel electrophoresis and photography - An application note." UVP Company applications note (1988) (PDF)

68. Sturm, N., Simpson, L., Degrave, W. and Morel, C., "Sensitive detection and schizodeme classification of Trypanosoma cruzi cells by amplification of kinetoplast minicircle DNA sequences: Use in diagnosis of Chagas Disease." Mol. Biochem. Parasitol. 33, 205-214 (1989) (PDF) 

69. Hughes, D., Shonekan, O. and Simpson, L., "Structure, organization and transcription of the bifunctional dihydrofolate reductase-thymidylate synthetase gene from Crithidia fasciculata: evidence of kinetoplastid transcriptional control signals." Mol. Biochem. Parasitol. 34, 155-166 (1989) (PDF)

70. Campbell, D.A., Spithill, T.W., Samaras, N., Simpson, A.M. and Simpson, L., "Sequence of a cDNA for the ND1 gene from Leishmania major: potential uridine addition in the polyadenosine tail." Mol. Biochem. Parasitol. 36, 197-200 (1989) (PDF) 

71. Shaw, J. and Simpson, L., "Characterization of a protein fraction containing cytochromes b and c1 from mitochondria of Leishmania tarentolae." Exptl. Parasitol. 68, 443-449(1989)(PDF)

72. Simpson, L. and Shaw, J., "RNA editing and the mitochondrial cryptogenes of kinetoplastid protozoa." Cell. 57, 355-366 (1989) (PDF)

73. Shaw, J., Campbell, D. and Simpson, L., "Internal frameshifts within the mitochondrial genes for cytochrome oxidase subunit II and maxicircle unidentified reading frame 3 of Leishmania tarentolae are corrected by RNA editing: Evidence for translation of the edited cytochrome oxidase subunit II mRNA." Proc. Natl. Acad. Sci. USA. 86, 6220-6224 (1989) (PDF)  

74. Simpson, A.M., Suyama, Y., Dewes, H., Campbell, D. and Simpson, L., "Kinetoplastid mitochondria contain functional tRNAs which are encoded in nuclear DNA and also contain small minicircle and maxicircle transcripts of unknown function." Nucl. Acids Res. 17, 5427-5445 (1989) (PDF)

75. Campbell, D., Suyama, Y. and Simpson, L., "Genomic organization of nuclear tRNAGly and tRNALeu genes in Trypanosoma brucei". Mol. Biochem. Parasitol. 37, 257-262 (1989)(PDF)

76. Bakalara, N., Simpson, A.M. and Simpson, L., "The Leishmania kinetoplast-mitochondrion contains terminal uridylyltransferase and RNA ligase activities" J. Biol. Chem. 264, 18679-18686 (1989) (PDF)  

1990

77. Blum, B., Bakalara, N. and Simpson, L., "A model for RNA editing in kinetoplastid mitochondria: "Guide RNA" molecules transcribed from maxicircle DNA provide the edited information." Cell. 60, 189-198 (1990) (PDF)

78. Sturm, N. and Simpson, L., "Partially edited mRNAs for cytochrome b and subunit III of cytochrome oxidase from Leishmania tarentolae mitochondria: RNA editing intermediates." Cell 61, 871-878 (1990)  (PDF)

79. Sturm, N. and Simpson, L., "Kinetoplast DNA minicircles encode guide RNAs for editing of cytochrome oxidase subunit III mRNA." Cell. 61, 879-884 (1990)  (PDF)

80. Blum, B. and Simpson, L., "Guide RNAs in kinetoplastid mitochondria have a non-encoded 3' oligo(U) tail involved in recognition of the preedited region. Cell 62, 391-397 (1990) (PDF)

81. Avila, H., Goncalves, A., Nehme, N., Morel, C. and Simpson, L., "Schizodeme analysis of Trypanosoma cruzi stocks from South and Central America by analysis of PCR-amplified minicircle variable region sequences." Mol. Biochem. Parasitol. 42, 175-188 (1990)  (PDF)

82. Simpson, L. "RNA editing--A Novel Genetic Phenomenon?". Science 250, 512-513 (1990) (PDF)

1991

83. Blum, B., Sturm, N., Simpson, A.M. and Simpson, L. "Chimeric gRNA/mRNA molecules with oligo- (U) tails covalently attached at sites of RNA editing suggest that uridine addition occurs by transesterification." Cell 65, 1-8 (1991)  (PDF)

84. Degrave, W., Thiemann, O., Goncalves, A., Avila, H., Sturm, N., Simpson, L. and Morel, C.M. "Development of tools for diagnosis and epidemiological studies of Chagas Disease: Detection and strain typing." In Molecular and Immunological Aspects of Parasitism (Wang, C.C., Ed.) Amer. Assoc. Advance. Sci. pp. 177-185 (1991)  

85. Lake, J., , de la Cruz, V., Ferreira, P., Morel, C. and Simpson, L., "Evolution of parasitism: Kinetoplastid protozoan history reconstructed from mitochondrial rRNA sequences (Correction)" Proc. Natl. Acad. Sci. U.S.A. 88, 2612 (1991)  (PDF)

86. Avila,H.A., Sigman,D.S., Cohen,L.M., Millikan,R.C. and Simpson, L., "Polymerase chain reaction amplification of Trypanosoma cruzi kinetoplast minicircle DNA isolated from whole blood lysates: diagnosis of chronic Chagas' disease." Mol. Biochem. Parasitol. 48, 211-222 (1991) (PDF)

87. Sturm,N.R. and Simpson, L., "Leishmania tarentolae minicircles of different sequence classes encode single guide RNAs located within the variable region approximately 150 bp from the conserved region." Nucl. Acids Res. 19, 6277-6281 (1991) (PDF)

1992

88. Maslov, D.A., Sturm, N.R., Niner, B.M., Gruszynski,E.S., Peris, M. and Simpson, L., "An intergenic G-rich region in Leishmania tarentolae kinetoplast maxicircle DNA is a pan-edited cryptogene encoding ribosomal protein S12." Mol. Cell. Biol. 12, 56-67 (1992) (PDF)

89. Rovai, L., Tripp, C., Stuart, K. and Simpson, L., "Recurrent polymorphisms in small chromosomes of Leishmania tarentolae after nutrient stress or subcloning." Mol. Biochem. Parasitol. 50, 115-126 (1992) (PDF)

90. Simpson, A.M.,  Bakalara, N. and Simpson, L., "A ribonuclease activity is activated by heparin or by digestion with proteinase K in mitochondrial extracts of Leishmania tarentolae." J. Biol. Chem. 267, 6782-6788 (1992) (PDF)

91. von Haeseler, A., Blum, B., Simpson, L., Sturm, N. and Waterman, M.S., "Computer methods for locating kinetoplastid cryptogenes." Nucl. Acids Res. 20, 2717-2724 (1992) (PDF)

92. Maslov, D.A. and Simpson, L., "The polarity of editing within a multiple gRNA-mediated domain is due to formation of anchors for upstream gRNAs by downstream editing." Cell 70, 459-467 (1992) (PDF)

93. Sturm, N.R., Maslov, D.A., Blum, B. and Simpson, L. "Generation of unexpected editing patterns in Leishmania tarentolae mitochondrial mRNAs: Misediting produced by misguiding." Cell 70, 469-476 (1992) (PDF)

94. Blum, B. and Simpson, L., "Formation of gRNA/mRNA chimeric molecules in vitro, the initial step of RNA editing, is dependent on an anchor sequence." Proc. Natl. Acad. Sci. USA, (1992) 89, 11944-11948. (PDF)

1993

95. Simpson, L., Maslov, D.A. and Blum, B., "RNA editing in Leishmania mitochondria." In RNA Editing: The Alteration of Protein Coding Sequences of RNA. (Benne, R., Ed.) Ellis Horwood Series in Molecular Biology, Simon and Schuster International Group, Hemel Hempstead, 53-83 (1993)

96. Avila, H.A., Borges Pereira, J., Thiemann, O., DePaiva, E., Degrave, W., Morel, C., and Simpson, L., "Detection of Trypanosoma cruzi in blood specimens of chronic chagasic patients by polymerase chain reaction amplification of kinetoplast minicircle DNA: comparison with serology and xenodiagnosis." J. Clin. Microbiol. 31, 2421-2426 (1993) (PDF)

97. Stuart K., Tripp, C., Maslov, D., Simpson, L. and Myler, P.J., "The molecular and transcriptional organization of the multicopy circular form of the LD1 genomic sequence of Leishmania.", Proceedings of the CSIR Golden Jubilee Symposia, in Current Trends In Leishmania Res., A.N. Bhaduri, et al, eds., Publications & Information Directorate (CSIR), New Delhi, 137-151 (1993)

98. Maslov, D.A., Elgort, M.G., Wong, S., Peckova, H. Lom, J., Simpson, L. and Campbell, D.A., "Organization of mini-exon and 5srRNA genes in the kinetoplastid Trypanoplasma borelli." Mol. Biochem. Parasitol. 61, 127-136 (1993)  (PDF)

99. Scheinman, A., Aguinaldo, A., Simpson, A., Peris, M., Simpson, L. and Lake, J., Reconstitution of a minimal small ribosomal subunit." In The Translation Apparatus, (K. Nierhaus, S. Franceschi, A. Subramanian, E. Erdmann and B. Wittmann-Liebold, Eds.) Plenum Press, New York, pp.719-726 (1993) (PDF)

100. Simpson, L., Simpson, A.M., and Blum, B., "RNA editing in Leishmania mitochondria". In RNA Processing - A Practical Approach. (Hames D. and Higgins, S., Eds.) IRL Press, (1993) (PDF)

1994

101. Maslov, D.A., Avila, H.A., Lake, J. A., and Simpson, L., "Evolution of RNA Editing in Kinetoplastid Protozoa: Pan Editing Preceded 5'-Editing." Nature 368, 345-348, (1994) (PDF)

102. Peris, M., Frech, G.C., Simpson, A.M., Bringaud, F., Byrne, E., Bakker, A., and Simpson, L. "Characterization of two classes of ribonucleoprotein complexes possibly involved in RNA editing from Leishmania tarentolae mitochondria." EMBO Journal 13, 1664-1672 (1994) (PDF)

103. Simpson, L., and Maslov, D.A. "RNA Editing and the Evolution of Parasites." Science 264, 1870-1871 (1994) (PDF) 

104. Simpson, L. and Maslov, D.A. "Ancient origin of RNA Editing in kinetoplastid Protozoa". In Current Opinion in Genetics and Development 4, 887-894 (1994) (PDF)

105. Maslov, D.A. and Simpson, L. "Evolution of Parasitism in Kinetoplastid Protozoa." Parasitology Today 11, 30-32 (1994) (PDF)

106. Maslov, D.A. and Simpson, L. "RNA editing and mitochondrial genomic organization in the Cryptobiid kinetoplastid protozoan Trypanoplasma borreli." Mol. Cell. Biol. 14, 8174-8182 (1994) (PDF)

107. Thiemann, O.H., Maslov, D.A. and SImpson, L. "Disruption of RNA editing in Leishmania tarentolae by the loss of minicircle-encoded guide RNA genes." EMBO J. 13, 5689-5700 (1994) (PDF)

108. Maslov, D.A., Thiemann, O. and Simpson, L. "Editing and misediting of transcripts of the kinetoplast maxicircle G5 cryptogene in an old laboratory strain of Leishmania tarentolae." Mol. Biochem. Parasitol. 68, 155-159 (1994) (PDF)

1995

109. Simpson, L. "From Molecular Evolution to Biomedical Research: The Case of Charles Darwin and Chagas' Disease". In Evolution and the Molecular Revolution (Marshall, C. and Schopf, J.W., eds.) Boston: Jones and Bartlett. 125-148 (1995) (PDF)

110. Frech, G. C., Bakalara, N., Simpson, L. and Simpson, A. "In vitro RNA Editing-like Activity in a Mitochondrial Extract from Leishmania tarentolae". EMBO Journal. 14, 178-187 (1995) (PDF)

111. Bringaud, F., Peris, M., Zen, K.H., and Simpson, L. "Characterization of two nuclear-encoded protein components of mitochondrial ribonucleoprotein complexes from Leishmania tarentolae". Mol. Biochem. Parasitol. 71, 65-79 (1995) (PDF)

112. Byrne, E., Bringaud, F., and Simpson, L. "RNA-protein interactions in the ribonucleoprotein T-complexes in a mitochondrial extract from Leishmania tarentolae". Mol. Biochem. Parasitol. 72, 65-76 (1995) (PDF)

113. Simpson, L. and Thiemann, O. "Sense from Nonsense: RNA Editing in Mitochondria of Kinetoplastid Protozoa and Slime Molds". Cell. 81, 837-840, (1995) (PDF)

114. Yasuhira, S. and Simpson. L. "Minicircle-encoded guide RNAs from Crithidia fasciculata." RNA. 1, 634-643 (1995) (PDF)

115. Bringaud, F., Peyruchaud, S., Baltz, D., Giroud, C., Simpson, L. and Baltz, T. "Molecular characterization of the mitochondrial heat shock protein 60 gene from Trypanosoma brucei". Mol. Biochem. Parasitol. 74, 119-123 (1995) (PDF)

116. Avila, H.A., and Simpson, L., "Organization and Complexity of Minicircle-encoded guide RNAs in Trypanosoma cruzi. RNA. 1, 939-947 (1995) (PDF)

1996

117. Simpson, L. and Emeson, R. "RNA Editing". Annu. Rev. Neurosci. 19, 27-52 (1996) (PDF)

118. L. Simpson, G. C. Frech, and D. Maslov. "RNA Editing in Trypanosomatid Mitochondria". In Methods In Enzymology (G. Attardi, ed.) 264, 99-121 (1996) (PDF)

119. Maslov, D.A., Lukes, J., Jirku, M. and Simpson, L., "Phylogeny of Trypansomes as inferred from the small and large subunit rRNAs: implications for the evolution of parasitism in the trypanosomatid protozoa". Mol. Biochem. Parasitol. 75. 197-206 (1996) (PDF)

120. Ramos, A., Maslov, D.A., Fernandes, O., Campbell, D.A. and Simpson, L., "Detection and Identification of Human Pathogenic Leishmania and Trypanosoma Species by Hybridization of PCR-amplified Mini-Exon Repeats". Exptl. Parasitol. 82, 242-250 (1996) (PDF)

121. Lima, B. and Simpson, L., "Sequence-dependent in vivo importation of tRNAs into the mitochondrion of Leishmania tarentolae". RNA 2, 429-440 (1996)  (PDF)

122. Frech, G.C. and Simpson, L. " Uridine Insertion into Pre-edited mRNA by a Mitochondrial Extract from Leishmania tarentolae: Stereochemical Evidence for the Enzyme Cascade Model." Mol. Cell. Biol. 16, 4584-4589 (1996)(PDF)

123. Thiemann, O.H. and Simpson, L. "Analysis of the 3' uridylylation sites of guide RNAs from Leishmania tarentolae". Mol. Biochem. Parasitol. 79, 229-234 (1996) (PDF)

124. Yasuhira, S. and Simpson, L. "Guide RNAs and guide RNA genes in the cryptobiid kinetoplastid protozoan, Trypanoplasma borreli." RNA. 2, 1153-1160 (1996) (PDF)

125. Byrne, E., Connell, G.J., and Simpson, L. "Guide RNA-directed uridine-insertion RNA editing in vitro." EMBO Journal. 15, 6758-6765 (1996) (PDF)

125a. Lyubchenko Y.L., Blankenship R.E., Gall A.A., Lindsay S.M., Thiemann O., Simpson L., Shlyakhtenko L.S. "Atomic force microscopy of DNA, nucleoproteins and cellular complexes: the use of functionalized substrates." Scanning Microsc Suppl;10:97-107; discussion 107-9 (1996)  

1997

126. Connell, G.J., Byrne, E., and Simpson, L. "Guide RNA-independent and Guide RNA-dependent Uridine-Insertion into Cytochrome b mRNA in a Mitochondrial Lysate from Leishmania tarentolae." J. Biol. Chem. 14, 4212-4218 (1997) (PDF)

127. Yasuhira, S. and Simpson, L. "Phylogenetic affinity of mitochondria of Euglena gracilis and kinetoplastids using cytochrome oxidase I and hsp60. J. Mol. Evol. 44, 341-347 (1997)  (PDF)

128. Peris, M., Simpson, A.M., Grunstein, J., Liliental, J.E., Frech, G.C. and Simpson, L. "Native gel analysis of ribonucleoprotein complexes from a Leishmania tarentolae mitochondrial extract." Mol. Biochem. Parasitol. 85, 9-24 (1997) (PDF)

129. Simpson, L. "The genomic organization of guide RNA genes in kinetoplastid protozoa: several conundrums and their solutions." Mol. Biochem. Parasitol. 86, 133-141(1997)  (PDF)

130. Bringaud, F, Stripecke, R., Frech, G.C., Freedland, S., Turck, C., Byrne, E. and Simpson, L. "Mitochondrial Glutamate Dehydrogenase from Leishmania tarentolae is a Guide RNA-binding Protein." Mol. Cell Biol. 17, 3915-3923 (1997) (PDF)

131. Simpson, L. and Thiemann, O.H., "mRNA editing". In Eukaryotic Messenger RNA Processing (Krainer, A., Ed.) Frontiers in Molecular Biology, IRL Press, London, 335-376 (1997) (PDF)

132. Simpson, L. and Kretzer, F. "The mitochondrion in dividing Leishmania tarentolae cells is symmetric and circular and becomes a single asymmetric tubule in non-dividing cells due to division of the kinetoplast portion." Mol. Biochem. Parasitol. 87, 71-78 (1997) (PDF)

133. Alfonzo, J.D., Thiemann, O. and Simpson, L. "The mechanism of U-insertion/deletion RNA editing in kinetoplastid mitochondria." Nucl. Acids Res. 25, 3751-3759 (1997) (cover)  (PDF)

1998

134. Simpson, L., Wang, S., Thiemann, O.H., Alfonzo, J.D., Maslov, D. and Avila, H. "U-insertion/deletion Edited Sequence Database." Nucl. Acids Res. 26, 170-176 (1998)  (PDF)

135. Simpson, L. "A base called J." Proc. Natl. Acad. Sci. USA. (Commentary) 95, 2037-2038 (1998) (PDF)

136. Aphasizhev, R., Karmarkar, U. and Simpson, L. "Are tRNAs imported into the mitochodria of kinetoplastid protozoa as 5'-extended precursors?". Mol. Biochem. Parasitol. 15, 73-80 (1998) (PDF)

137. Thiemann, O.H., Alfonzo, J.D. and Simpson, L. "Cloning and characterization of Leishmania tarentolae adenine phosphoribosyltransferase." Mol. Biochem. Parasitol. 95, 141-146 (1998)  (PDF)

138. Alfonzo, J.D., Thiemann, O.H. and Simpson, L. "Purification and characterization of MAR1: a mitochondrial associated ribonuclease from Leishmania tarentolae. J. Biol. Chem. 273, 30003-30011 (1998)  (PDF)

139. Connell, G.J. and Simpson, L. "The Role of RNA Structure in RNA Editing". In RNA Structure and Function (R. Simons and M. Grunberg-Manago, eds.), Cold Spring Harbor Laboratory Press. Cold Spring Harbor, N.Y. (1998) (PDF)

140. Simpson, L. "RNA Editing: An Evolutionary Perspective." In RNA World, Second Edition (R. Gesteland, J. Atkins and T. Cech, eds.) Cold Spring Harbor Press. Cold Spring Harbor, N.Y. (1998) (PDF)

141. Simpson, L. "RNA Editing" In Frontiere Della Vita (G. Attardi and F. Amaldi, eds.) Instituto della Encliclopedia Italiana, Fondata da Giovanni Trecanni. Origin and Evolution of Life, Vol. I, 483-496 (1998) (PDF)

1999

142. Kapushoc, S. and Simpson, L. "In vitro uridine insertion RNA editing mediated by cis-acting guide RNAs." RNA. 5, 656-669 (1999) (PDF)

143. Estevez, A.M., Kierszenbaum, F., Wirtz, E., Bringaud, F. Grunstein, J. and Simpson, L. "Knockout of the glutamate dehydrogenase gene in bloodstream Trypanosoma brucei in culture has no effect on editing of mitochondrial mRNAs." Mol. Biochem. Parasitol. 100, 5-17 (1999)  (PDF)

144. Maslov, D.A., Yasuhira, S. and Simpson, L. "Phylogenetic affinities of Diplonema within the Euglenozoa as inferred from the SSU rRNA gene and partial COI protein sequence. Protist 150, 33-42 (1999) (PDF)

145. Simpson, L. and Maslov, D.A. "Evolution of the U-insertion/deletion RNA editing in mitochondria of kinetoplastid protozoa." In Molecular Strategies in Biological Evolution (L.H. Caporale, ed.) Annal. N.Y. Acad. Sci. 870, 190-205 (1999)(PDF)

146. Simpson, L. "Protists on the Web." Protist. 150, 109-112 (1999)  (On-line text)

147. Blanc, V., Alfonzo, J.D., Aphasizhev, R. and Simpson, L. "The Mitochondrial RNA Ligase from Leishmania tarentolae Can Join RNA Molecules Bridged by a Complementary RNA." J. Biol. Chem. 274, 24289-24296 (1999)  (PDF)

148. Estevez, A.E., Thiemann, O.H. Alfonzo, J.D. and Simpson, L. "T7 RNA polymerase-driven transcription in mitochondria of Leishmania tarentolae and Trypanosoma brucei." Mol. Biochem. Parasitol. 103, 251-259 (1999)  (PDF)

149. Alfonzo, J.D., Blanc, V., Estevez, A.M., Rubio, M.A.T. and Simpson, L. "C to U editing of anticodon of imported mitochondrial tRNATrp allows decoding of UGA stop codon in Leishmania tarentolae." EMBO J. 18, 7056-7062 (1999)  (PDF)

150. Estevez, A.M. and Simpson, L., "Uridine insertion/deletion RNA editing in trypanosome mitochondria - a review." Gene. 240, 247-260 (1999) (PDF)

2000

151. Simpson, L., Thiemann, O.H., Savill, N.J., Alfonzo, J.D. and Maslov, D.A. "Evolution of RNA Editing in Trypanosome Mitochondria". Proc. Natl. Acad. Sci. USA. 97, 6986-6993 (2000)  (PDF)

152. Rubio, M.A., Liu, X., Yuzawa, H., Alfonzo, J.D. and Simpson, L. "Selective Importation of RNA into Isolated Mitochondria from Leishmania tarentolae." RNA. 6, 988-1003 (2000) (PDF)

153. Stephen T. Kapushoc, Juan D. Alfonzo, Mary Anne T. Rubio, and Larry Simpson. "End processing precedes mitochondrial importation and editing of tRNAs in Leishmania tarentolae". J. Biol. Chem. 275, 37907-14 (2000) (PDF)

2001

154. Carillo, R., Thiemann, O.H., Alfonzo, J.D. and Simpson, L. (2001) Uridine insertion/deletion RNA editing in Leishmania tarentolae mitochondria shows cell cycle dependence. Mol. Biochem. Parasitol. 113 175-181 (PDF)

155. Aphasizhev, R. and Simpson, L. (2001) Isolation and characterization of a U-specific 3'-5' exonuclease from mitochondria of Leishmania tarentolae. J. Biol. Chem. 276, 21280-21284 (PDF)

156. Simpson, L. (2001) Protist Web Alert: From Parasites to Life in Space! Protist. 152(1), 31-2 (PDF)

157. Simpson, L. (2001) Protist Web Alert: Some Marine Protists of Ill-Repute. Protist 152, 113-114 (PDF)

158. Simpson, L. (2001) RNA Editing. In Frontiers of Science, Academic Press. Vol. 1: The Origins of Life (PDF)

159. Gao, G., Kapushoc, S., Simpson, A.M., Thiemann, O.H. and Simpson, L. Guide RNAs of the recently isolated LEM125 strain of Leishmania tarentolae: an unexpected complexity. RNA. 7(9),1335-47. (PDF)

160. Simpson, L. (2001) Protist Web Alert: Memories of Times Past. Protist 152, 183-184 (PDF)

161. Simpson, L. (2001) Protist Web Alert: The Chlamy Crowd on the Web. (PDF)

162. Simpson, L. (2001) Meeting Report: World Leish II, Crete, Greece, May 20-24, 2001. Protist 152,169-173 (PDF)

2002

163. Kapushoc, S. T., Alfonzo, J. A. and Simpson, L. Differential localization of nuclear-encoded tRNAs between the cytosol and mitochondrion in Leishmania tarentolae. RNA. 8, 57-68 (2002) (PDF)

164. Ruslan Aphasizhev, Sandro Sbicego, Marian Peris, Sei-Heon Jang, Inna Aphasizheva, Agda M. Simpson, Anatoly Rivlin and Larry Simpson. Trypanosome Mitochondrial 3' Terminal Uridylyl Transferase (TUTase): The Key Enzyme in U-insertion/deletion RNA Editing. Cell 108, 637-648 (2002) (PDF)

165. Simpson, L. Protist Web Alert: Malaria- The Biological Terminator. Protist 153, 7-8 (2002) (PDF)

166. Simpson, L. (2002) Protist Web Alert: Poetry and Pictures. Protist 153, 109-110 (2002) (PDF)

167. Crain, P.F., Alfonzo, J.D., Rozenski, J., Kapushoc, S.T., McCloskey, J.A. and Simpson, L. (2002) Modification of the universally unmodified uridine-33 in a mitochondria-imported edited tRNA and the role of the anticodon arm structure on editing efficiency. RNA. 8, 752-761 (PDF)

168. Monzani, P.S., J. D. Alfonzo, L. Simpson, G. Oliva and O.H. Thiemann (2002) Cloning, characterization and preliminary crystallographic analysis of Leishmania hypoxanthine-guanine phosphoribosyl transferase. Biochim. Biophys. Acta 1598, 3-9 (PDF)

169. Simpson, L. (2002) Protist Web Alert: The Ciliates Among Us. Protist. 153, 221-222. (PDF)

174. Simpson, L. (2002) Protist Web Alert: The Best of Times. Protist. 153, 365. (PDF)

2003

171. Aphasizhev, R., Aphasizheva, I., Nelson R. and Simpson, L. (2003) A 100 kDa complex of two RNA-binding proteins from mitochondria of Leishmania tarentolae catalyzes RNA annealing and interacts with several RNA editing components. RNA. 9, 62-76 (PDF)

172. Tomonori Kaneko, Takeo Suzuki, Stephan T. Kapushoc, Mary Anne Rubio, Jafar Ghazvini, Kimitsuna Watanabe, Larry Simpson and Tsutomu Suzuki. (2003)Wobble modification differences and subcellular localization of tRNAs in Leishmania tarentolae: implication for tRNA sorting mechanism. EMBO J. 22, 657-667 (PDF)

173.Ruslan Aphasizhev, Inna Aphasizheva, Robert E. Nelson, Guanghan Gao, Agda M. Simpson, Xuedong Kang, Arnold M. Falick, Sandro Sbicego and Larry Simpson. (2003) Isolation of a U-insertion/deletion editing complex from Leishmania tarentolae mitochondria. EMBO J. 22, 913-934. (PDF) (Supplementary material) (Sequences not yet in Genbank)

174. Simpson, L., Sbicego, S. and Aphasizhev, R. (2003) Review: Uridine insertion/deletion RNA editing in trypanosome mitochondria: A complex business. RNA. 9, 265-276 (PDF)

175. Sandro Sbicego, Juan D. Alfonzo, Antonio M. Estévez, Mary Anne T. Rubio, Xuedong Kang, Christoph W. Turck , Marian Peris and Larry Simpson (2003) RBP38, a novel RNA-binding protein from trypanosomatid mitochondria, modulates RNA stability. Eukary. Cell. 2, 560-568. (PDF)

176. Hong, M. and Simpson, L. Genomic Organization of Trypanosoma brucei Kinetoplast DNA minicircles. Protist. (2003) 154, 265-279 (PDF)

177. Gao, G. and Simpson, L. Is the Trypanosoma brucei REL1 RNA ligase specific for U-deletion editing and the REL2 RNA ligase specific for U-insertion editing? J. Biol. Chem. 278(30):27570-4 (PDF)

178. Aphasizhev, R., I. Aphasizheva and L. Simpson. (2003) A tale of two Tutases. Proc. Natl. Acad. Sci. USA. 100: 10617-10622 (PDF) (Commentary by Jonatha Gott)

2004

179. Kang, X., Falick, A.M., Nelson, R.E., Gao, G., Rogers, K., Aphasizhev, R. and Simpson, L. (2004) Disruption of the zinc finger motifs in the Leishmania tarentolae LC-4 (=TbMP63) L-complex editing protein affects the stability of the L-complex. J. Biol. Chem. 279(6):3893-9 (PDF)

180. Martina Neboháová, Dmitri A. Maslov, Arnold M. Falick and Larry Simpson (2004) The Effect of RNAi Down Regulation of RET1 3' TUTase on Mitochondrial de novo Protein Synthesis and Stability of Respiratory Complexes in Trypanosoma brucei. J. Biol. Chem. 279: 7819-7825  (PDF)

181. Larry Simpson, Ruslan Aphasizhev, Guanghan Gao and Xuedong Kang Simpson, L. (2004) Mitochondrial proteins and complexes in Leishmania and Trypanosoma involved in U-insertion/deletion RNA editing. RNA. 10: 159-170 (PDF)

182. Robert E. Nelson, Inna Aphasizheva, Arnold M. Falick, Martina Nebohacova and Larry Simpson (2004) The I-complex in Leishmania tarentolae is a uniquely-structured F1-ATPase. Mol.Biochem.Parasitol. 135, 221-224 (PDF)

183. Inna Aphasizheva, Ruslan Aphasizhev and Larry Simpson (2004) RNA Editing Terminal Uridylyl Transferase 1: Identification of Functional Domains by Mutational Analysis. J. Biol. Chem. 279, 24123-24130 (PDF)

184. Simpson, L. (2004) A Shameless Advertisement. Protist. 155 (PDF)

185. Aphasizhev, R., Aphasizheva, I. and Simpson, L. (2004) Multiple Terminal Uridylyltransferases of Trypanosomes. FEBS Letters. 572, 15-28 (PDF)

2005

186. Kang, Xuedong, Rogers, Kestrel, Gao, Guanghan, Falick, Arnold M., Zhou, Sharleen and Simpson, Larry (2005) Reconstitution of uridine deletion pre-cleaved RNA editing with two recombinant enzymes. Proc. Natl. Acad. Sci. USA. 102: 1017-1022 (PDF)

187. Guanghan Gao, Agda M. Simpson, Xuedong Kang, Kestrel Rogers, Martina Nebohacova and Larry Simpson (2005) Functional complementation of Trypanosoma brucei RNA in vitro editing with recombinant RNA ligase. Proc. Natl. Acad. Sci. USA.  102, 4712-4717 (PDF)

188. Trager, L., Spielman, A. and Simpson L. (2005) Malaria, Not Down and Certainly Not Out. A,. J. Trop. Med. Hyg. 73, 824-5 (PDF)

189. Sherman, I. and Simpson L. (2005) In Memoriam: William Trager (1910-2005) J Eukaryot Microbiol. 52(3):173-6 (PDF)

2006

190. Simpson, L. (2005) Uridine insertion/deletion RNA editing as a paradigm for site-specific modifications of RNA molecules. (Gesteland, Cech and Atkins, eds.) The RNA World, Third Edition. Cold Spring Harbor Press, N.Y. 2005 (PDF)

191. Simpson, L. (2006) Who am I? Protist. 157, 89 (PDF)

192. Simpson, L. (2006) Protists on the Web - Redoux. Protist. 157, 255-258 (PDF)

193. Maslov, D., Butler, E., Sharma, M., Falick, A., Gingery, M., Agrawal, R., Spremulli, L. and Simpson, L. (2006) Isolation and Characterization of Mitochondrial Ribosomes and Ribosome Subunits from Leishmania tarentolae. Mol. Biochem. Parasitol. 148, 69-78 (PDF)

194. Kang, X., Gao, G., Rogers, K., Falick, A., Zhou, S. and Simpson, L. (2006) Reconstitution of full round uridine-deletion RNA editing with three recombinant proteins. Proc. Natl. Acad. Sci. USA. 103, 13944-13949 (PDF)

194. Simpson, L. (2006) Death of the "ologies". Protist 157, 361-362 (PDF)

2007

195. Simpson, L. (2007) My Personal Epiphany. Protist. 158  (PDF)

196. Maslov, D., Spremulli, L. Sharma, M., Bhargava, K., Grasso, D., Falick, A., Agrawal, R., Parker, C. and Simpson, L. (2007) Proteomics and electron microscopic characterization of the unusual mitochondrial ribosome-related 45S complex in Leishmania tarentolae. Mol. Biochem. Parasitol. 152(2):203-12 (PDF)

197. Maslov, D. and Simpson, L. (2007) Strategies of Cryptogene Discovery and Analysis. Methods in Enzymol. 2007;424:127-39 (PDF)

198. Rogers, K, Gao, G. and Simpson, L. (2007) Uridylate-Specific 3'-5' exoribonucleases involved in Uridylate-deletion RNA editing in trypanosomatid mitochondria. J. Biol. Chem. 282:29073 (PDF)

2008

199. Simpson, L. (2008) What is Science and why do we do it? Protist 159, 3 (PDF)

200. Jensen, R.E., Simpson, L. and Englund, P. (2008) What happens when Trypanosoma brucei leaves Africa? Trends in Parasitol. 24: 428-431 (PDF

2009

201. Osato, D., Rogers, K., Li, Feng, Guo, Qiang, Richmond, Greg, Klug, Felix and Simpson, L.. In search of the editosome. (2009) RNA. 15:1338-1344 (PDF) (Suppl. material)

202. Simpson, L. Science is a Hard  Mistress. (2009) Protist. 160: 481-482 (PDF)

203. Manjuli R. Sharma, Timothy M. Booth, Larry Simpson, Dmitri A. Maslov, and Rajendra K. Agrawal. Structure of a mitochondrial ribosome with minimum RNA. (2009) PNAS. 106: 9637-9642 21. (PDF)

204. Li, F., Ge, P., Hui, W. Atanasov, I, Rogers, K., Guo, Q., Osato, D., Falick, A., Zhou, H. and Simpson, L. Structure of the core editing complex (L-complex) involved in uridine insertion/deletion RNA editing in trypanosomatid mitochondria. (2009) PNAS 106:12306-12310. (PDF) (PDF of Supplemental Material) (AVI movie of single particle reconstruction)

205. Simpson, L. (2009). Musings on the real problems. Protist. (2009) 160(1): 3 (PDF)

206. Simpson, L., Aphasizhev, R., Lukes, J. and Cruz-Reyes, J. (2009). Guide to the nomenclature of kinetoplastid editing. Protist. 161, 2-6 (PDF)

207. Nebohácová M, Kim CE, Simpson L, Maslov DA. (2009) RNA editing and mitochondrial activity in promastigotes and amastigotes of Leishmania donovani. Int J Parasitol. 2009 39(6):635-44 (PDF)

2010

208. Gao, G., Rogers, K., Li, F., Guo, Q., Osato, D., Zhou, S., Falick, A. and Simpson, L. (2010). Uridine insertion/deletion RNA editing in Trypanosomatids: Specific stimulation in vitro of Leishmania tarentolae REL1 RNA ligase activity by the MP63 zinc finger protein. Protist. 161, 489-496 (PDF)

209. Simpson, L. (2010). A Personal Scientific Odyssey. (2011) Protist 162, 188-206 (PDF)

2011

210. Feng Li, Jeremy Herrera, Sharleen Zhou and Larry Simpson. (2011)
Trypanosome REH1 is an RNA helicase involved with the 3'-5' polarity of multiple gRNA-guided uridine insertion/deletion RNA editing. (2011) PNAS  108(9):3542-7 (PDF)

2012

211. Eckers, E., Cyrklaff, C., Simpson, L. and Deponte, M. (2012). Mitochondrial protein import pathways are functionally conserved among eukaryotes despite compositional diversity of the import machineries. J. Biol. Chem. 393, 513-524 (PDF) (Suppl. Material) (Cover)

212. Simpson, L. (2012) The Wonder of it All. Trends in Genetics. 28(9): 419-420. (PDF)

2013

213. Sherman, I. and Simpson L. (2013). William Trager - 1910-2005. A Biographical Memoir. Proc. Natl. Acad. Sci US  (PDF)

2015

214. Simpson,L.(2015). The most unlikely places. RNA 21:740  (PDF) 

215. Simpson, Douglass, Lake, Pelligrini and Li (2015). PLOS Neglected Diseases. Comparison of the Mitochondrial Genomes and Steady State Transcriptomes of Two Strains of the Trypanosomatid Parasite, Leishmania tarentolae (PDF) (PLOS web site)

216. Wong, R.G., Kazane, K., Maslov, D., Rogers, K., Aphasizhev, R. and Simpson. L. (2015).U-insertion/deletion RNA editing multiprotein complexes and mitochondrial ribosomes in Leishmania tarentolae are located in antipodal nodes adjacent to the kinetoplast DNA. Mitochondrion. (PDF) (OnLine version)