Gene: CR4 (G4)
Species: Trypanosoma brucei
Notes: (1) Two sites of variation in the 3' end of the editing domain are either 1U or 2U at nt
545 of mRNA
(2) BF and PF T.brucei have different consensus sequences (nt 231 to nt
301). The fully edited sequence only occurs in BF cells.
(3) In the DNA sequence there is an A present after nt 100, a T absent at nt 105 and a G absent at nt 109.
(4) In the edited RNA sequence there is an A present after nt 201, and a G absent at nt 212.
1 ---------+---------+---------+ - - -- -- - --+--- 43
DNA TAATTTATTGTTATCTTTGTGTATTTATTA A A AA GG G GCTTTA
RNA-ed UAAUUUAUUGUUAUCUUUGUGUAUUUAUUAuuAuuuuAuuuuAAuuuuGGuuGuGC Auuu
1 ---------+---------+---------+---------+---------+------ ---+ 60
44 - ----- +--- - - ---- +------ - -- + - - - 73
A GTTTG GTTG G G ATTG ATCTATG A GG A A A G
uuuuuuuuuuuAuuuG GuG UGuuuGuGuuuuA UGuA C A GuuuAuGGuAuAuuuuAuuGuu
61 ---------+------ --- +---------+-- ---- - - -+---------+---------+ 120
AA M Y S L W Y I L L L
1 - - - - - - - - - + 10
74 - - - - --+-- -- - --- - + - - - - -- 96
G G G G GTTTG TG G GGG A G A G G A AG
GuuuuGuuuuuuGuuuuuGuuGUUUGuuUGuGuGGGuAuGuuuuAuuuGuuuuGuuAuAG
121 ---------+---------+---------+---------+---------+---------+ 180
F C F L F L L F V C V G M F Y L F C Y S
11 - - - - - - - - - + - - - - - - - - - + 30
97 - - - + ------- - -+ - ---- - ---+- - - -- 125
G G G G TTTGTGG G GA A GTTG G GTTTA G A AG
uuGuuuGuuuuuuuuuGuuGuUUUG GGuuGuGAuuuuuuAuuG GuGuuuuG AuuGuAuAG
181 ---------+---------+----- ----+---------+--- ------+- --------+ 240
C L F F F V V L G C D F L L V F W L Y S
31 - - - - - - - - - + - - - - - - - - - + 50
126 - - --+- - -- --- - - + - - 142
A G GACG A AA TTG A A G G G
uuuAuuuuuuuuGuGACGuuAuAAuuUUGuuuAuuuuuuuuuuuuAuuuuGuuuuGuGuu
241 ---------+---------+---------+---------+---------+---------+ 300
L F F L W R Y N F V Y F F F L F C F V F
51 - - - - - - - - - + - - - - - - - - - + 70
143 - - ----- + ---- - -- --+--- ---- - 168
G A GTTTG A TTGG G GG GTTTTA GTTG G
uuuuGuAuuG UUGuuuuuAuUUGGuuuGuuuGGuuuuuuuuuG UAuuuuuuGUUGuGuuu
301 ---------+ ---------+---------+---------+--- ------+---------+ 360
F V L L F L F G L F G F F L Y F L L C F
71 - - - - - - - - - + - - - - - - - - - + 90
169 - + - -- - - - -- -+ ---------+ - 191
G G A GA A A G TG TG GGGTTTTGTG G
uGuGuuAuuuuuuGAuuuAuuuuuuAuGuUGuuuuuUGuuuuGGG UG GuuuuuuuGuuuu
361 ---------+---------+---------+---------+----- -- --+---------+ 420
V L F F D L F F M L F F V L G G F F V F
91 - - - - - - - - - + - - - - - - - - - + 110
192 - - - - - - - -+ - - - - -- - 207
G G A G G A G GG G G A G AG G
uGuuuuuuuuuuuuGuuuAuGuuuGuuuuuAuuuGuGGuuGuuGuuAuuuuGuuAGuuuG
421 ---------+---------+---------+---------+---------+---------+ 480
V F F F C L C L F L F V V V V I L L V W
111 - - - - - - - - - + - - - - - - - - - + 130
208 - - +--- - -- - - -+--------- +- ------ - -+- -- -- 245
G G GTTG A TG G A ATTTTGGTTTA TA ATTGCG A AGA AA TA
GuuGuuGUUGuuAuuUGuGuAuA GGUUUAuuUAuA UGCGuuuuuuAuuuuAGAuAAuUAu
481 ---------+---------+--- ------+----- ----+---------+---------+ 540
L L L L F V Y R F I Y M R F L F *
131 - - - - - - - - - + - - - - - - 146
246 ----+---------+---------+---------+---- 283
GTTTTGTTTTTATTTTGGTTTTATAAAATGTTTTTTCT
G G UA UUGGUUUUAUAAAAUGUUUUUUCU
541 - - -- -----+---------+-------- 568