Gene: NADH dehydrogenase 3 (ND3,G5,CR5)
Species: Trypanosoma brucei
Edited/unedited: edited
Notes: Two editing domains. The large 5' domain is edited to a single 
consensus sequence. The small 3' domain (nt 375-395) shows several 
editing patterns, yielding two C-terminal amino acid sequences, 
one of which is shown below.




       1 ---------+---------+---------+--------  -     +--   -    ----- 48
DNA      TCAAAAAATCCTCGCCTTTTTACTTTAGTTTGTTATCA  A     ATA   G    TGTAT
RNA-ed   UCAAAAAAUCCUCGCCUUUUUACUUUAGUUUGUUAUCAuuAuuuuuAuAuuuGuuuuUG A 
       1 ---------+---------+---------+---------+---------+--------- +  60
A.A.       K  K  S  S  P  F  Y  F  S  L  L  S  L  F  L  Y  L  F  L   I  
       1   -  -  -  -  -  -  -  -  -  +  -  -  -  -  -  -  -  -  -   +  20


      49 -+  - --   ------    +   - ---         - -      - -      -  +-  71
         TA  G GG   ATTTTA    A   A AGG         A G      A G      A  GC 
         UAuuGuGGuuuA  UUAuuuuAuuuAuAGGuuuuuuuuuAuGuuuuuuAuGuuuuuuAuuGC
      61 ---------+--  -------+---------+---------+---------+---------+  120
           L  W  F  I    I  L  F  I  G  F  F  L  C  F  L  C  F  L  L  H 
      21   -  -  -  -    -  -  -  -  -  +  -  -  -  -  -  -  -  -  -  +  40


      72 -       --  -    --  -  -   + --    -- - -- --+ - -- - --- -   98
         A       GA  G    CG  G  G   G GG    CG G GG TTG A GA A GAA T
         AuuuuuuuGAuuGuuuuCGuuGuuGuuuGuGGuuuuCGuGuGGuUUGuAuGAuAuGAAuU
     121 ---------+---------+---------+---------+---------+---------+  180
           F  F  D  C  F  R  C  C  L  W  F  S  C  G  L  Y  D  M  N  S 
      41   -  -  -  -  -  -  -  -  -  +  -  -  -  -  -  -  -  -  -  +   60


      99 -+--   -----    - -+-  ---   ---    -  -+ -- ---      - -  -   128
         CACG   GTGTG    A ACA  GGA   ATG    G  AG TG TTG      G A  G 
         CACGuuuG GUGuuuuAuACAuuGGAuuuAUGuuuuGuuAGuUGuUUGuuuuuuGuAuuGu
     181 -------- -+---------+---------+---------+---------+---------+  240
           R  L   V  F  Y  T  L  D  L  C  F  V  S  C  L  F  F  V  L  L  
      61   -  -   -  -  -  -  -  -  -  +  -  -  -  -  -  -  -  -  -  +   80 


     129  -+-  --- --   - - -+--  -   -     ---- -+- -  -    -     -    155
          AAA  CCA TA   G G TTTG  G   G     GTGA ATG G  G    A     G  
         uAAAuuCCAuUAuuuGuGuUUUGuuGuuuGuuuuuGUGAuA GuGuuGuuuuAuuuuuGuu
     241 ---------+---------+---------+---------+ ---------+---------+  300
           N  S  I  I  C  V  L  L  F  V  F  V  I   V  L  F  Y  F  C  Y 
      81   -  -  -  -  -  -  -  -  -  +  -  -  -   -  -  -  -  -  -  +  100


     156 ----      + ----- --     -      -  + - - - ------+-  -- - -- -     87
         ATGG      G TTTTG GG     G      G  G A G A AGTTTTGA  TG G GG A  
         AUGGuuuuuuGuUUUUGuGGuuuuuGuuuuuuGuuGuAuGuAuAG    GAuuUGuGuGGuAuu
     301 ---------+---------+---------+---------+-----    ----+---------+  360
           G  F  L  F  L  W  F  L  F  F  V  V  C  I  G      F  V  W  Y  F 
     101   -  -  -  -  -  -  -  -  -  +  -  -  -  -  -      -  -  -  -  +  120


     188    --+------- - -+---------+--------    -   + ------   ---+----  234
            GGGATCACTG A ATTTGTGTGGTGTAATTTTA    G   A GATTTG   TTTGTTGT
         uuuGGGAUCAC GuAuAUUUGUGUGGUGUAAUUUUAuuuuGuuuAuGA  UGuuuUUUGUUGU
     361 ---------+- --------+---------+---------+-------  --+---------+  420
           W  D  H   V  Y  L  C  G  V  I  L  F  C  L  W    C  F  L  L  Y 
     121   -  -  -   -  -  -  -  -  -  +  -  -  -  -  -    -  -  -  -  +  140


     235 -----+---------+---------+---------+---------  279
         ATTATACATATTATATTAATAAATATATAAAATAATAAAATACTA
         AUUAUACAUAUUAUAUUAAUAAAUAUAUAAAAUAAUAAAAUACUA
     421 ---------+---------+---------+---------+-----  465
           Y  T  Y  Y  I  N  K  Y  I  K  *
     141   -  -  -  -  -  -  -  -  -  +                 150